Description: CD146 is a cell surface
glycoprotein, originally identified as a melanoma antigen, whose
expression is associated with tumor progression and the
development of metastatic potential. Overexpression of CD146 in
breast carcinoma cells results in a more cohesive cell growth and
in the formation of smaller tumors in nude mice. During
implantation and placentation, CD146 is expressed by the
intermediate trophoblast in the placental site and binds to its
putative receptor in uterine smooth muscle cells thus limiting
trophoblastic invasion in the myometrium.
Species Cross-reactivity: Mouse
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on melanoma
using anti-CD146 polyclonal antibody
1. Lehmann J.M., Riethmueller G., Johnson J.P.; "MUC18, a
marker of tumor progression in human melanoma, shows sequence
similarity to the neural cell adhesion molecules of the
immunoglobulin superfamily."; Proc. Natl. Acad. Sci. U.S.A.
2. Sers C., Kirsch K., Rothbaecher U., Riethmueller G., Johnson
J.P.; "Genomic organization of the melanoma-associated
glycoprotein MUC18: implications for the evolution of the
immunoglobulin domains."; Proc. Natl. Acad. Sci. U.S.A.