human CD24 antigen is a small heavily glycosylated,
glycosylphosphatidylinositol (GPI)linked cell surface protein. It
consists of a small protein core comprising 27 amino acids, which
is extensively glycosylated and is bound to the membrane via a
phosphatidylinositol anchor. The human CD24 antigen is
physiologically expressed in developing or regenerating tissue, as
well as in granulocytes, keratinocytes and renal tubular
epithelium. It modulates B-cell activation responses. Signaling
could be triggered by the binding of a lectin-like ligand to the
CD24 carbohydrates, and transduced by the release of second
messengers derived from the GPI-anchor.
Species Cross-reactivity: Human
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on human
spleen using anti-CD24 polyclonal antibody
1. Kay R, Rosten PM, Humphries RK. CD24, a signal transducer
modulating B cell activation responses, is a very short peptide
with a glycosyl phosphatidylinositol membrane anchor. J Immunol
1991; 147: 1412-1416
2. Aigner S, Ruppert M, Hubbe M, Sammar M, Sthoeger Z, Butcher
EC, Vestweber D, Altevogt P. Heat stable antigen (mouse CD24)
supports myeloid cell binding to endothelial and platelet P-selectin.
Int Immunol 1995; 7: 1557-1565