Description: NGFR p75 or CD271 is a 75kD
transmembrane glycoprotein consisting of an extracellular domain
which contains four cysteine rich domains responsible for ligand
binding, a transmembrane domain, and a cytoplasmic domain. NGFR
p75 displays paradoxical functions when acting alone or with other
receptor proteins. Working in concert with Trk receptors, it
recognizes neurotrophins and transmits trophic signals into the
cell. NGFR p75 is necessary for regulating neuronal growth,
migration, differentiation and cell death during development of
the central and peripheral nervous system.
Species Cross-reactivity: Mouse , Rat
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on D3
(A) and PC12 (B) using
anti-CD271 polyclonal antibody.
1."Low-affinity nerve-growth factor receptor
(p75NTR) can serve as a receptor for rabies
virus."Tuffereau C., Benejean J., Blondel D.,
Kieffer B., Flamand A.EMBO J. 17:7250-7259(1998)
2."Solid tumor proteome and phosphoproteome
analysis by high resolution mass
spectrometry."Zanivan S., Gnad F., Wickstroem S.A.,
Geiger T., Macek B., Cox J., Faessler R., Mann M.J.
Proteome Res. 7:5314-5326(2008)