80/B7-1 polyclonal antibody
CD8 antigen is a cell surface glycoprotein found on most cytotoxic
T lymphocytes that mediates efficient cell to cell interactions
within the immune system. Cluster of Differentiation 8 (CD8) is a
disulphide-linked heterodimer consisting of the unrelated α and
β subunits. Each subunit is a glycoprotein composed of a single
extracellular Ig-like domain, a polypeptide linker, a
transmembrane part and a short cytoplasmic tail. CD8 alpha chains
binds to class I MHC molecules alpha-3 domains. CD8 is thought to
play a role in the process of T-cell mediated killing.
Species Cross-reactivity: Mouse
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on mouse Thymus
using anti-CD8 polyclonal antibody
1.Liaw C.W., Zamoyska R., Parnes J.R.; "Structure,
sequence, and polymorphism of the Lyt-2 T cell differentiation
antigen gene."; J. Immunol. 137:1037-1043(1986).
2.Youn H.J., Harriss J.V., Gottlieb P.D.; "Nucleotide
sequence analysis of the C.AKR Lyt-2a gene: structural
polymorphism in alleles encoding the Lyt-2.1 T-cell surface
alloantigen."; Immunogenetics 28:345-352(1988).
3.Zamoyska R., Vollmer A.C., Sizer K.C., Liaw C.W., Parnes J.R.;
"Two Lyt-2 polypeptides arise from a single gene by
alternative splicing patterns of mRNA."; Cell