Anti-CD10  polyclonal antibody  (Rabbit)                   Catalog0805-4   

Product Description: Neprilysin(CD10) is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide. peptides. Neprilysin is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid.

Species Cross-reactivity:  Human , Mouse , Rat

Formulation:   0.43mg/ml

Application(s):   WB: 1:500

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

  

Fig: Western blot analysis on mouse kidney using anti-CD18 polyclonal antibody

 

References:
1.Malfroy B., Kuang W.-J., Seeburg P.H., Mason A.J., Schofield P.R.; "Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)."; FEBS Lett. 229:206-210(1988).
2.Turner AJ, Isaac RE, Coates D, et al. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function [J]. Bioessays, 2001,23:261-269.
3.Oefner C, D’Arcy A, Hennig M, et al. Structure of Human Neutral Endopeptidase (Neprilysin) Complexed with Phosphoramidon [J]. J Mol Biol, 2000, 296:341-349.