Anti-CD105(Endoglin)  polyclonal antibody  (Rabbit)        Catalog:0902-1        

Product Description: Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia type 1. This condition leads to frequent nose bleeds, telangiectases on skin and mucosa and may cause arteriovenous malformations in different organs including brain, lung, and liver.

Species Cross-reactivity:  Mouse 

Formulation:   0.73mg/ml

Application(s):   WB: 1:500

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified.

  

Fig: Western blot analysis on D3 using anti CD105 polyclonal antibody.

 

References:
1."Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand."Ge A.Z., Butcher E.C.Gene 138:201-206(1994)
2."Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells."St Jacques S., Cymerman U., Pece N., Letarte M.Endocrinology 134:2645-2657(1994)