polyclonal antibody (Rabbit)
is a type I membrane glycoprotein located on cell surfaces and is
part of the TGF beta receptor complex. The protein consists of a
homodimer of 180 kDA with disulfide links. It has been found on
endothelial cells, activated macrophages, fibroblasts, and smooth
muscle cells. Endoglin has been found to be part of the TGF-beta1
receptor complex. It thus may be involved in the binding of
TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. In humans
endoglin may be involved in the autosomal dominant disorder known
as hereditary hemorrhagic telangiectasia type 1. This condition
leads to frequent nose bleeds, telangiectases on skin and mucosa
and may cause arteriovenous malformations in different organs
including brain, lung, and liver.
Species Cross-reactivity: Mouse
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw
Purity: Immunogen affinity purified.
Fig: Western blot analysis on D3 using anti
CD105 polyclonal antibody.
1."Cloning and expression of a cDNA encoding mouse endoglin,
an endothelial cell TGF-beta ligand."Ge A.Z., Butcher
2."Molecular characterization and in situ localization of
murine endoglin reveal that it is a transforming growth
factor-beta binding protein of endothelial and stromal
cells."St Jacques S., Cymerman U., Pece N., Letarte