Anti-E-Cadherin, polyclonal antibody  (Rabbit)                     Catalog0407-25 

Product Description: Cadherins are calcium-dependent cell adhesion proteins. The classic cadherin subfamily includes N-, P-, R-, B- and E-cadherins as well as about ten other members which are found in adherens junctions (AJ), E-cadherin is found at the junctions of epithelial cells. Besides mediating cell-cell adhesion through homophilic interactions, E-cadherin mediates contact inhibition of cell growth, and loss of E-cadherin is associated with tumorigenesis. E-cadherin expression is frequently down-regulated or extinguished in malignancy which strongly correlates with poor prognosis.

Species Cross-reactivity:  Human , Mouse

Formulation:   0.45mg/ml

Application(s):     WB: 1:500

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA.
 
Storage Instruction: Store at +4°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

     
Fig: Western blot analysis on A431 using anti-E-Cadherin polyclonal antibody

 

References:
1.Ponta H, Hofmann M & Herrlich P. Recent advances in the genetics of metastasis. Eur J Cancer, 1994,30A(13):1995.
2.Mareel M, Bracke M & VanRoy F. Cancer metastasis: negative regulation by an invasion-suppressor complex. Cancer Detect Prev, 1995,19(5):451.
3.Nagufuchi A, Shirayoshi Y, Okazaki K, et al. Transformation of cell adhesion properties by exogenously introduced E-cadherindherin cDNA. Nature, 1987, 329(6137):341.