polyclonal antibody (Rabbit)
Description: An epidermal growth factor
receptor (EGFR) is a 170-kDa glycoprotein formed from a single
polypeptide chain of 1186 amino acids can be divided into a number
of functional domains. The heavily glycosylated 622-amino acid
residue amino-terminal extracellular domain contains the growth
factor binding site. EGFR is a transmembrane receptor tyrosine
kinase (RTK) that mediates the biological signal of small
polypeptide mitogens, including epidermal growth factor (EGF) and
transforming growth factor-α.
Species Cross-reactivity: Human , Mouse , Rat
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA.
Storage Instruction: Store at +4°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on
A431 using anti-EGFR polyclonal antibody
1.Paria B.C., Das S.K., Andrews G.K., Dey S.K.;
"Expression of the epidermal growth factor
receptor gene is regulated in mouse blastocysts
during delayed implantation."; Proc. Natl.
Acad. Sci. U.S.A. 90:55-59(1993).
2.Luetteke N.C., Phillips H.K., Qiu T.H., Copeland
N.G., Earp H.S., Jenkins N.A., Lee D.C.; "The
mouse waved-2 phenotype results from a point
mutation in the EGF receptor tyrosine kinase.";
Genes Dev. 8:399-413(1994).