Anti-EGFR, polyclonal antibody  (Rabbit)                        Catalog0407-21

Product Description: An epidermal growth factor receptor (EGFR) is a 170-kDa glycoprotein formed from a single polypeptide chain of 1186 amino acids can be divided into a number of functional domains. The heavily glycosylated 622-amino acid residue amino-terminal extracellular domain contains the growth factor binding site. EGFR is a transmembrane receptor tyrosine kinase (RTK) that mediates the biological signal of small polypeptide mitogens, including epidermal growth factor (EGF) and transforming growth factor-α.

Species Cross-reactivity:  Human , Mouse , Rat

Formulation:   0.5mg/ml

Application(s):     WB: 1:1000

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA.
 
Storage Instruction: Store at +4°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

     
Fig: Western blot analysis on A431 using anti-EGFR polyclonal antibody

 

References:
1.Paria B.C., Das S.K., Andrews G.K., Dey S.K.; "Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation."; Proc. Natl. Acad. Sci. U.S.A. 90:55-59(1993).
2.Luetteke N.C., Phillips H.K., Qiu T.H., Copeland N.G., Earp H.S., Jenkins N.A., Lee D.C.; "The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase."; Genes Dev. 8:399-413(1994).