Anti-Flt3, polyclonal antibody  (Rabbit)             Catalog0804-1

Product Description: CD135 is a cytokine receptor expressed on the surface of hematopoietic progenitor cells. FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets. CD135 is a proto-oncogene. Mutations of the Flt3 receptor can lead to the development of leukemia, a cancer of bone marrow hematopoietic progenitors.

Species Cross-reactivity:  Mouse

Formulation:   0.5 mg/ml

Application(s):    WB:1:1,000  

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

.  

Fig: Western blot analysis on mouse brain using anti-Flt3 polyclonal antibody

 

References:
1.Matthews W., Jordan C.T., Wiegand G.W., Pardoll D., Lemischka I.R.; "A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations."; Cell 65:1143-1152(1991).
2.Maroc N., Rottapel R., Rosnet O., Marchetto S., Lavezzi C., Mannoni P., Birnbaum D., Dubreuil P.; "Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase."; Oncogene 8:909-918(1993).