Anti-GM-CSF-R-alpha (CD116), polyclonal antibody  (Rabbit)                 Catalog:0804-8

Product Description: The granulocyte macrophage–colony-stimulating factor receptor (GM-CSF-R) is a heterodimer composed of 2 subunits,αand ß, and ligand binding to the high-affinity receptor leads to signalling for the multiple actions of GM-CSF on target cells. The GM-CSF receptors are found on the surface of myeloid precursors, granulocytes, mononuclear phagocyte, and also frequently present on the myeloid malignancies. The GM-CSF-R-alpha transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Species Cross-reactivity:  Mouse

Formulation:   0.48 mg/ml

Application(s):    WB:1:1,000   

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

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Fig: Western blot analysis on F9 cell lysates using anti- GM-CSF-R-alpha polyclonal antibody.

 

References:
1. Lanza F, Moretti S, Papa S, et al. Report on the fifth interna tional workshop on human leukocyte differentiation antigens. Boston, November 3 -7, 1993, Haematologica, 1994,79:374~386
2. Lanza F, Castagnar B, Rigolin G, et al. Flow cytometry measurement of GM-CSF receptors in acute leukemic blasts, and normal hemopoietic cells. Leukem ia, 1997, 11: 1700~1710
3. Jubinsky P T, Laurie A S, Nathan D G, et al. Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha sub unit. Blood, 1994, 84:4174~4185