polyclonal antibody (Rabbit)
Description: ST2 known as IL1RL1，a membrane
protein，belongs to the interleukin-1 receptor family with three
Ig-like C2-type (immunoglobulin-like) domains and a TIR domain.
Predominantly ST2 expressed in hematopoietic tissues, and in
macrophage,erythroid, epithelial and fibroblast cell lines. ST2 is
a receptor for interleukin-33 (IL-33) which upon stimulation
recruits the signaling molecules MYD88, IRAK1, IRAK4, and TRAF6,
followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2,
MAPK14, and MAPK8.
Species Cross-reactivity: Mouse
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on D3 using anti-
IL1RL1 polyclonal antibody.
1."Alternative promoter usage of the Fos-responsive gene
Fit-1 generates mRNA isoforms coding for either secreted or
membrane-bound proteins related to the IL-1
receptor."Bergers G., Reikersdorfer A., Braselmann S.,
Graninger P., Busslinger M.EMBO J. 13:1176-1188(1994)
2.“The IL-33/ST2 pathway: therapeutic target and novel
biomarker.”Kakkar R, Lee RT.Nat 。Rev Drug Discov. 2008