(CD127 or CDw127),
polyclonal antibody (Rabbit)
IL-7 cytokine plays a major role in the in vivo maintenance of
polyclonal naive and memory T cells, positively regulating the
survival, differentiation and proliferation of thymocyte and
peripheral T lymphocyte populations. IL-7 exerts its biological
function through the IL-7 receptor which is expressed on pre-B
cells, thymocytes and bone marrow-derived macrophages. The IL-7
receptor is composed of an IL-7 receptor-specific chain and the
IL-2 receptor γ chain common to the IL-2, IL-4,IL-7, IL-9 and
IL-15 receptors. Soluble forms of the IL-7 Rα have been reported.
Species Cross-reactivity: Human
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on K562(A) and
human skin tissue (B)using anti- IL-7R-alpha
1. Yu L.-R., Zhu Z., et al. "Improved titanium dioxide
enrichment of phosphopeptides from HeLa cells and high confident
phosphopeptide identification by cross-validation of MS/MS and
MS/MS/MS spectra."; J. Proteome Res. 6:4150-4162(2007).
2. Roifman C.M., Zhang J., et al. "A partial deficiency of
interleukin-7R alpha is sufficient to abrogate T-cell
development and cause severe combined immunodeficiency.";
3. Gregory S.G., Schmidt S., Seth P., et al. "Interleukin 7
receptor alpha chain (IL7R) shows allelic and functional
association with multiple sclerosis."; Nat. Genet.