D-interacting substrate 220,
Mouse monoclonal IgG1
D-interacting substrate 220 (Kidins220), also known as ARMS (ankyrin-rich
membrane spanning) is an integral plasma membrane protein
predominantly expressed in brain and neurons that presents a
polarized location in neural cells, concentrating at the tip of
extending neurites and in plasma membrane micro-domains
corresponding to lipid rafts. The primary amino acid sequence of
Kidins220 reveals 11 ankyrin repeats, 4 trans-membrane domains, a
proline-rich region, a sterile-α motif (or SAM) domain, and a
type I postsynaptic density-95/discs large/zonula occludens-1 (PDZ)-binding
motif at the very C-terminus.
Species Cross-reactivity: Mouse
1:500~1:1,000 ICC 1:100~1:500
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on recombinant
protein of Kidins220, the detected band is 48kDa.
1." Identification and cloning of Kidins220, a novel
neuronal substrate of protein kinase D.” Iglesias T, Cabrera-Poch
N, Mitchell MP, Naven TJ, Rozengurt E, Schiavo G. J Biol Chem.
2."Large-scale phosphorylation analysis of mouse
liver."Villen J., Beausoleil S.A., Gerber S.A., Gygi
S.P.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007)