Anti-NCAM-L1, polyclonal antibody  (Rabbit)                    Catalog0805-5           

Product Description: The neural cell adhesion molecule L1 (NCAM-L1) is an immunoglobulin superfamily adhesion molecule that is critical for neural development, involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Defects in L1CAM are the cause of hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS). Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid in the brain causes increased intracranial pressure inside the skull. Defects in L1CAM are also the cause of mental retardation, aphasia, shuffling gait, and adducted thumbs syndrome (MASA), a X-linked disorder.

Species Cross-reactivity:  Human , Mouse , Rat

Formulation:   0.62 mg/ml

Application(s):    WB 1:500 - 1:1000

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

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Fig: Western blot analysis on fetal brain using anti-NCAML1 polyclonal antibody

 

References:
1.Kobayashi M., Miura M., Asou H., Uyemura K.; "Molecular cloning of cell adhesion molecule L1 from human nervous tissue: a comparison of the primary sequences of L1 molecules of different origin."; Biochim. Biophys. Acta 1090:238-240(1991).
2.Hlavin M.L., Lemmon V.; "Molecular structure and functional testing of human L1CAM: an interspecies comparison."; Genomics 11:416-423(1991).
3.Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.; "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."; Cell 127:635-648(2006).