polyclonal antibody (Rabbit)
neural cell adhesion molecule L1 (NCAM-L1) is an immunoglobulin
superfamily adhesion molecule that is critical for neural
development, involved in neuron-neuron adhesion, neurite
fasciculation, outgrowth of neurites, etc. Defects in L1CAM are
the cause of hydrocephalus due to stenosis of the aqueduct of
Sylvius (HSAS). Hydrocephalus is a condition in which abnormal
accumulation of cerebrospinal fluid in the brain causes increased
intracranial pressure inside the skull. Defects in L1CAM are also
the cause of mental retardation, aphasia, shuffling gait, and
adducted thumbs syndrome (MASA), a X-linked disorder.
Species Cross-reactivity: Human , Mouse , Rat
WB 1:500 - 1:1000
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative: 0.05% Sodium Azide.
Storage Instruction: Store at +4°C after thawing.
Aliquot store at -20°C or -80°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig: Western blot analysis on
fetal brain using anti-NCAML1 polyclonal
1.Kobayashi M., Miura M., Asou H., Uyemura K.;
"Molecular cloning of cell adhesion molecule L1
from human nervous tissue: a comparison of the
primary sequences of L1 molecules of different
origin."; Biochim. Biophys. Acta
2.Hlavin M.L., Lemmon V.; "Molecular structure
and functional testing of human L1CAM: an
interspecies comparison."; Genomics
3.Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar
C., Mortensen P., Mann M.; "Global, in vivo,
and site-specific phosphorylation dynamics in
signaling networks."; Cell 127:635-648(2006).