Anti-TIE-1 polyclonal antibody  (Rabbit)              Catalog:0804-11

Product Description: The Tie-1 receptor is an endothelial specific cell surface tyrosine kinase that is indispensable for endothelial functions. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Tie-1 and Tie-2 are receptor tyrosine kinases (RTKs) that are exclusively expressed in endothelial cells and play important roles in endothelial cell biology.

Species Cross-reactivity: Human , Mouse , Rat

Formulation:   0.46 mg/ml

Application(s):   WB: 1:5,000

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

  

Fig: Western blot analysis on K562 cell lysates using anti-Tie1 polyclonal antibody

 

References:
1.PuriMC, Rossant J,Alitalo K,et al.The receptor tyrosine kinase Tie is required for integrity and survival of Vascular endothelial cells[J].EMBO J, 1995, 14(5): 5884-5891.
2.Partanen J., Armstrong E. et al. "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains." Mol. Cell. Biol. 12:1698-1707(1992).
3.The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004).