HRP Conjugated, polyclonal antibody (Rabbit)
Description: Myc gene encodes for a transcription factor
that is believed to regulate expression of 15% of all genes
through binding on Enhancer Box sequences (E-boxes) and recruiting
histone acetyltransferases (HATs). c-Myc is commonly activated in
a variety of tumor cells and plays an important role in cellular
proliferation, differentiation, apoptosis and cell cycle
progression. This c-Myc antibody detects endogenous levels of
total c-Myc protein and is also for detection of Myc-tagged fusion
Species Cross-reactivity: Human
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA.
Storage Instruction: Store at +4°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
Fig1: Western blot analysis on myc-tagged
recombinant protein using c-myc antibody HRP
1. "A quantitative atlas of mitotic
phosphorylation."Dephoure N., Zhou C., Villen J.,
Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc.
Natl. Acad. Sci. U.S.A. 105:10762-10767(2008)
2. "Transactivation of gene expression by Myc is inhibited
by mutation at the phosphorylation sites Thr-58 and
Ser-62."Gupta S., Seth A., Davis R.J. Proc. Natl. Acad. Sci.