Anti-CD44 Mouse monoclonal IgM          Catalog:M0108-5

Product Description: CD44 is a cell-surface glycoprotein postulated to play a role in a variety of biological processes, including lymphocyte homing and tumor-cell metastasis. It mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA), and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is highly polymorphic, possesses a number of alternative splice variants and undergoes extensive post-translational modifications.

Species Cross-reactivity:  Human

Formulation:   0.5 mg/ml

Application(s):   WB: 1:500-1:1000

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

  

Fig: Western blot analysis on Hela using anti-CD44 monoclonal antibody.

 

References:
1. Haynes BF et al .Cancer Cells ,1991;3(9):347-350
2. Korfuruta et al .Clin Cancer Res ,1998;4:21-29
3. Lokeshwar VB et al .J Biol Chem,1991;266(27):17983
4. Kalomiris EJ Biol Chem,1989;264(14):8113-8119
5. Lokeshwar VB et al .J Biol Chem ,1992;267(31):22073