Anti-CD62E (E-selectin, ELAM-1) polyclonal antibody  (Rabbit)             Catalog0805-6 

Product Description: CD62E, known as E-selectin, is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The main ligands recognised by CD62E are oligosaccharides related to sialyl lewis x. P-selectin has a similar function, but is expressed on the endothelial cell surface within minutes as it is stored within the cell rather than produced on demand.

Species Cross-reactivity:  Human , Mouse , Rat

Formulation:   0.52 mg/ml

Application(s):   WB: 1:500

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

  

Fig: Western blot analysis on Jurkat using anti-CD62E polyclonal antibody

 

References:
1.Phillips M.L., Nudelman E., et al: "ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex."; Science 250:1130-1132(1990).
2.Mills A.; "Modelling the carbohydrate recognition domain of human E-selectin."; FEBS Lett. 319:5-11(1993).
3.Collins T., Williams A., Johnston G.I., et al; "Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1."; J. Biol. Chem. 266:2466-2473(1991).