polyclonal antibody (Rabbit)
Description: Cyclooxygenase-1(Cox-1) and
cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze
the formation of PGH2 from arachidonic acid. Cox1 is expressed
constitutively in most tissues, while Cox2 expression is induced
by lipopolysaccaride (LPS) and peptoglycan (PGN). PGN activates
Ras, leading to phosphorylation of Raf at Ser338 and Erk 1/2 at
Tyr204). Both Cox1 and Cox2 play a role in the neuropathology of
Alzheimer's disease by potentiating γ-secretase activity and β-amyloid
generation. Pharmacological inhibition of COX can provide relief
from the symptoms of inflammation and pain.
Species Cross-reactivity: Human , Mouse
Storage Buffer: 1*TBS (pH7.4), 0.5%BSA.
Storage Instruction: Store at +4°C. Avoid repeated freeze /
Purity: Immunogen affinity purified
A: NIH/3T3 B: 293T
Fig: Western blot analysis on Hela using
anti-COX-1 polyclonal antibody
1. Sakamoto C. Roles of COX-1 and COX-2 in gastrointestinal
pathophysiology. J Gastroenterol，1998，33（5）：618
2. Lee C, Chen KW , Sheu FS, et al . Studies of a
tumor-associated antigen， COX-1，recognized by a monoclonal
antibody. Cancer Immunol Immunother， 1992，35（1）：19
3. Takahashi Y., Ueda N.,et al.; "Immunoaffinity
purification and cDNA cloning of human platelet prostaglandin
endoperoxide synthase (cyclooxygenase)."; Biochem. Biophys.
Res. Commun. 182:433-438(1992).