Anti-DOPEY2, polyclonal antibody  (Rabbit)               Catalog0903-3,

Product Description: Dopey-2, a 2,298 amino acid protein, belongs to the dopey family, that is overexpressed in lymphoblasts from Down syndrome patients and Abundantly expressed in developing central nervous system, with highest levels in cerebellum and lowest in telencephalon. Multiple isoforms of Dopey-2 exist due to alternative splicing events. Dopey-2 is thought to play a role in protein trafficking between early endosomes and the late

Species Cross-reactivity:  Human , Mouse

Formulation:   3.38 mg/ml

Application(s):     WB: 1:250~1:500

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA.
 
Storage Instruction: Store at +4°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

     
Fig: Western blot analysis on human heart (A) and mouse heart (B) cell lysates using anti- DOPEY2 polyclonal antibody.

 

References:
1."C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning."Guipponi M., Brunschwig K., Chamoun Z., Scott H.S., Shibuya K., Kudoh J., Delezoide A.-L., El Samadi S., Chettouh Z., Rossier C., Shimizu N., Mueller F., Delabar J.-M., Antonarakis S.E. Genomics 68:30-40(2000)"
2."The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice." Lopes C., Chettouh Z., Delabar J.-M., Rachidi M. Biochem. Biophys. Res. Commun. 305:915-924(2003)