Anti-Noggin polyclonal antibody  (Rabbit)           Catalog:0805-2

Product Description: Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs. It is essential for cartilage morphogenesis and joint formation. Defects in NOG are the cause of multiple synostoses syndrome 1 (SYNS1), symphalangism proximal syndrome (SYM1) and tarsal-carpal coalition syndrome (TCC).

Species Cross-reactivity:  Human , Mouse , Rat

Formulation:   0.5 mg/ml

Application(s):   WB: 1:2,000   

Storage Buffer: 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
 
Storage Instruction: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
 
Purity: Immunogen affinity purified

  

Fig: Western blot analysis on MG-63 cell lysates using anti-CK18 polyclonal antibody

 

References:
1. Zimmerman LB, DeJesda-Escobar JM, Harland RM. The Spemann organizer signal Noggin binds and inactivates bone morphogenetic protein 4. Cell, 1996, 86:599~606.
2. Traister A, Abashidze S, Gold V, et al. BMP controls nitric oxide-mediated regulation of cell numbers in the developing neural tube. Cell Death Differ. 2004. 11:832~841.
3. Valenzuela D.M., Economides A.N., Rojas E., Lamb T.M., et al. "Identification of mammalian noggin and its expression in the adult nervous system."; J. Neurosci. 15:6077-6084(1995).